Threshold Concentrations for Ragweed and Birch Pollen in Seasonal Allergic Rhinitis

Inclusion criteria

• ✓. Able and willing to give written informed consent.
• ✓. Male and female subjects, aged 18-65 years. Women will be considered for inclusion if they are:
• ✓. Not pregnant, as confirmed by pregnancy test (see flow chart), and not nursing.
• ✓. Of non-child bearing potential (i.e. physiologically incapable of becoming pregnant, including any female who is post-menopausal, with documented proof of hysterectomy or tubal ligation, or meets clinical criteria for menopause and has been amenorrhoeic for more than 1 year prior to the screening visit).
• ✓. Of childbearing potential and using a highly effective birth control during the entire study as described in section 8.2.
• ✓. Body mass index between 18 and 35 kg/m2.
• ✓. History of seasonal allergic rhinitis to ragweed (July to September) or birch pollen (March to May).
• ✓. Positive skin prick test response (positive wheal diameter reaction of ≥ 3mm) for Ambrosia artemisiifolia or Betula pendula at screening or within 12 months prior to screening visit.

Exclusion criteria