Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain

Inclusion Criteria: * Patients ≥18 years old * Patients scheduled for amputation of upper or lower extremity (including digit, ray, and hand) as a primary or secondary sequela of trauma. * Patients scheduled for amputation of upper or lower extremity (including digit, ray, and hand) for primary or secondary sequelae of malignancy. * Secondary sequalae include but is not limited to metastatic disease and osteolytic disease. * Patients scheduled for amputation of upper or lower extremity (including digit, ray, and hand) for vasculitic diseases. Exclusion Criteria: * Patients less than 18 years old * Patients with cognitive impairment * Patients who are imprisoned at the time of randomization * Patients currently enrolled in other studies relating to neuropathic pain * Patients actively undergoing radiation therapy * Patients with existing neuroma or underwent prior neuroma surgery * Patients with amputations scheduled congenital reasons