CompletedPhase 2

Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron

Saudi Arabia90 participantsStarted 2022-04-15

Plain-language summary

One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention, vomiting, increased aspiration risk and consequently increased the length of hospital stay. In this study, investigators will evaluate Neostigmine's effect in reducing GRV in mechanically ventilated patients and compare its effect with metoclopramide and Ondansetron .

Who can participate

Age range25 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Mechanically ventilated ICU patients * With nasogastric tube feeding * Gastric Residual Volume \>120 mL (3hours after the last gavage) Exclusion Criteria: * History of diabetes * Heart block * Bradycardia (heart rate \<60/min) * Systolic blood pressure less than 90 mm Hg * Renal insufficiency * Using any prokinetic agents such as erythromycin or cisapride within 8 hours before study initiation * Recent surgery (10 days or less) on the stomach or digestive system * pregnancy and lactation * Occurrence of extrapyramidal side effects * Gastrointestinal (GI) bleeding

What they're measuring

Evaluation of Gastric Residual Volume(GRV)

Timeframe: 12 hours

Volume of the gastric antrum

Timeframe: 4 days

Trial details

NCT IDNCT05342818

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-30

View on ClinicalTrials.gov More Delayed Gastric Emptying trials