Budesonide Multimatrix(MMX) Versus Prednisolone in Management of Mild to Moderate Ulcerative Colitis

Inclusion Criteria: * This study will include patients with confirmed mild to moderate ulcerative colitis according to the Mayo score activity index with ages ranging between 18-60 years old. Exclusion Criteria: * Patients \< 18 years old. * Pregnant females. * Patients with proven infection with any enteric pathogens (e.g., Shigella species, Clostridium species, Salmonella species, ova, parasites, Clostridium difficile toxins A or B, or HIV infection). * Patients who received oral or rectal steroids in the last 4 weeks, immunosuppressive agents in the last 8 weeks, or anti-tumor necrosis factor agents in the last 3 months. * Patients with severe colitis (Mayo score \>11); Patients with evidence or history of toxic megacolon. * Severe anemia (hemoglobin \<10.5 g/dl), leucopenia, or granulocytopenia. * Patients using any cytochrome P450 inducers or inhibitors (e.g., ketoconazole, phenytoin) or antibiotics. * Patients with renal disease/insufficiency. * Patients with type I diabetes. * Patients with glaucoma. * Patients with malignancies. * Patients with decompensated liver cirrhosis (Child-Pugh score B and C). * Patients with COVID 19 infection.