This pilot study aims to evaluate if microchimeric cells in a patient with recurrent pregnancy loss (RPL) can be detected by the blood analysis for the presence of the DYS14 gene and the use of indel-panel methods and also, to examine if this method can distinguish the cell's origin; comparing gene sequence from the patient's firstborn son or her older brother. In addition, the pilot study will provide the investigators with information and experience necessary for a subsequent main study to be conducted.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Frequency of sRPL patients with microchimeric male cells
Timeframe: Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from older brother
Timeframe: Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from the patient's son
Timeframe: Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from the patient's daughter
Timeframe: Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from unknown person
Timeframe: Non-pregnant state, performed during study completion, i.e. within 1 year