CompletedNot Applicable

The Effect of Laparoscopic Splenectomy on the Immune Function for Cirrhosis Patients

China21 participantsStarted 2022-03-01

Plain-language summary

In this study, the investigators compared the improvement of and azygoportal disconnection related indicators in patients with liver cirrhosis after laparoscopic splenectomy. To determine whether surgical treatment can help enhance postoperative immune function and improve patient prognosis.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism, Platelet count \< 50\*10\^9/L * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy, * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy. * Uncontrolled Hypertension * Bleeding portal hypertension * Human immunodeficiency virus (HIV) infection

What they're measuring

The immune function CD4+ at 3 months after surgery

Timeframe: 3 months

The immune function CD4+ at 6 months after surgery

Timeframe: 6 months

The immune function CD4+ at 12 months after surgery

Timeframe: 12 months

The immune function CD4+ at 24 months after surgery

Timeframe: 24 months

The immune function CD8+ at 3 months after surgery

Timeframe: 3 months

The immune function CD8+ at 6 months after surgery

Timeframe: 6 months

The immune function CD8+ at 12 months after surgery

Timeframe: 12 months

The immune function CD8+ at 24 months after surgery

Timeframe: 24 months

Trial details

NCT IDNCT05339269

SponsorNorthern Jiangsu People's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-11-30

View on ClinicalTrials.gov More Cirrhosis, Liver trials