Phase 2a Study of HPG1860 in Subjects With NASH (NCT05338034) | Clinical Trial Compass
CompletedPhase 2
Phase 2a Study of HPG1860 in Subjects With NASH
United States89 participantsStarted 2021-11-22
Plain-language summary
This is a Phase 2a, randomized, double-blind, placebo-controlled, parallel group, multiple arm, multicenter study of 3 different doses of HPG1860 versus placebo in subjects with biopsy-confirmed or phenotypic NASH.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Provision of written informed consent prior to any study-specific procedure.
. Males and females between 18 and 75 years of age
. Nonpregnant, nonlactating women.
. Male subjects must agree to utilize a highly effective method of contraception.
. Body mass index (BMI) of ≥25 kg/m2 at Screening.
. Non-cirrhotic NASH subjects.
. NASH subjects with hepatic fat assessed by a central reader
. Willing and able to adhere to study restrictions and agree to comply with study protocol.
Exclusion criteria
. Pregnant or lactating females
. Current significant alcohol consumption
. Elevated LDL-C with stable dose of statin an or PCSK9 inhibitor
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.