Active — Not RecruitingNot Applicable

Deep Brain Stimulation Recovery in Treatment-Resistant Schizophrenia

Spain6 participantsStarted 2023-09-01

Plain-language summary

The purpose of this project is to improve the clinical response and personal recovery of patients with treatment-resistant schizophrenia (TRS).

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals aged 18-50 years * Meet DSM-5 criteria for schizophrenia, with a duration of illness \< than 15 years. * Meet updated TRS criteria. * Non-sustained response to electroconvulsive therapy. Exclusion Criteria: * Contraindications to neurosurgery or DBS * Epilepsy or seizures clozapine-induced * Suicidal or self-harming behaviour in the last 6 months * Other psychiatric disorders (including personality disorders) * Significant cognitive impairment (Vocabulary test WAIS IV-TR, IQ \<70, and SCIP\<55) * Severe medical non-controlled diseases * Pregnancy or breastfeeding * Substance use disorders (except nicotine)

What they're measuring

Positive and Negative Syndrome Scale for Schizophrenia (PANSS)

Timeframe: Changes from baseline score to 1-3 weeks scores and to fortnightly scores until the end of trial (12 months)

Trial details

NCT IDNCT05337904

SponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

View on ClinicalTrials.gov More Treatment-resistant Schizophrenia trials