This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. A total of 48 patients who had fully impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard extraction of the lower third molars, and the PRF group was formed with local PRF application in addition to standard impacted tooth surgery (n=96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Subjective parameters were pain assesment, swelling measurements on the face and limitation of mouth opening. Objective data is the analysis of serum values and anti-inflammatory markers in the blood.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Edema measurement
Timeframe: 2nd day posoperatively
Edema measurement
Timeframe: 7th day posoperatively
Trismus measurement
Timeframe: 2nd day postoperatively
Trismus measurement
Timeframe: 7th day postoperatively
Pain assesment
Timeframe: 2nd day postoperatively
Pain assesment
Timeframe: 7th day postoperatively
Erythrocyte sedimentation rate (ESR)
Timeframe: 2nd day postoperatively
Erythrocyte sedimentation rate (ESR)
Timeframe: 7th day postoperatively
C-reactive protein (CRP)
Timeframe: 2nd day postoperatively
C-reactive protein (CRP)
Timeframe: 7th day postoperatively
interleukin 6 (IL-6)
Timeframe: 2nd day postoperatively
interleukin 6 (IL-6)
Timeframe: 7th day postoperatively
tumor necrosis factor-alpha (TNF-α )
Timeframe: 2nd day postoperatively
tumor necrosis factor-alpha (TNF-α )
Timeframe: 7th day postoperatively