Dronabinol After Arthroscopic Surgery (NCT05335252) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Dronabinol After Arthroscopic Surgery
United States30 participantsStarted 2022-06-28
Plain-language summary
The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Patient who will undergo arthroscopic surgery of the knee including, but not limited to,
* Meniscectomy
* Synovectomy
* Chondroplasty
* Loose body removal
Exclusion Criteria:
* Patients under age 18 years
* Patients who cannot provide consent
* Patients who are pregnant, breast feeding, or are trying to become pregnant during the study period
* Patients with an allergy to any of the study drugs
* Patient who are lactose-intolerant
* Revision surgery
* Open surgery
* Comorbidities preventing surgery
* Patients with a history of mania, depression, or schizophrenia
* Patients taking any of the following drugs or supplements
* Anticholinergic agents
* Benzodiazepines
* Central nervous system depressants
* Droperidol
* Hydroxyzine
* Levomepromazine or methotrimeprazine
* Monoamine oxidase inhibitors
* Ritonavir
* Selective serotonin reuptake inhibitors
* Sympathomimetics
* St. John's Wort
* Current diagnosed alcohol or drug abuse
* Patients who cannot or will not abide by the medication restrictions listed below
Medication restrictions
* Participants must agree to abstain from using recreational or medical marijuana products or cannabidiol (CBD) in any form during the treatment period
* Participants should not drink alcohol or take other drugs while taking the study drug or hydrocodone/acetaminophen
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.