CompletedNot Applicable

Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy

Mexico109 participantsStarted 2021-01-01

Plain-language summary

In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality. Still, the combination of endoscopic variceal ligation and terlipressin-like treatment decreases the risks of rebleeding and mortality. This therapy with terlipressin usually was used for 72 hours. However, there are some studies demostrating that using terlipressin for 24 hours could control variceal bleeding with fewer side effects.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients of 18 years and older * Both genders, * Diagnosis of liver cirrhosis with a Child-Pugh score ≤ 11 (class B or C) * Acute variceal bleeding were included Exclusion Criteria: * Patients with contraindications to terlipressin (pregnancy, breastfeeding, or severe cardiopulmonary diseases), * Presence of sepsis, * Multi-organ failure, * The requirement of continuous ionotropic or ventilatory support, * Bleeding disorders, * Hepatocellular carcinoma or other extrahepatic malignanc.

What they're measuring

Compare the 24-h group vs 72-h group

Timeframe: The total study time ranges from the first day of telmipressin infusion to 6 weeks after the event

Trial details

NCT IDNCT05331768

SponsorInstituto Mexicano del Seguro Social

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2021-09-30

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