Individualized Duration of Antibiotic Treatment in Early Onset Infection in Newborns.

Inclusion Criteria: * Gestational age ≥ 35 weeks * Birth weight ≥ 2000 * Probable or possible infection according to the structured infection risk assessment * Sufficient size blood culture, preferably 0.5-1 ml, but at least 0.2 ml, drawn after onset of symptoms but before start of antibiotic treatment * Negative blood culture after 48 hours Exclusion Criteria: * Infants with positive blood culture * Blood culture volume prior to antibiotics of \< 0.2 ml * Site-specific infection as for example, meningitis or osteomyelitis * Infant fulfill current recommendation to stop antibiotic treatment at 36-48 hours; Low suspicion of sepsis initially including few and vague symptoms, CRP maximum 35-50 mg/l, negative blood culture and no symptoms after 48 hours of treatment