Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

Inclusion Criteria: * Fasting blood glucose between 100-125 mg/dL * BMI of 30-35 kg/m2 Exclusion Criteria: * History of liver disease, cardiovascular disease, overt diabetes, or cancer * Prescribed medications for hyperglycemia or dyslipidemia * Use of dietary supplements, prebiotics, or probiotics * Usage of antibiotics or anti-fungals within 3 months prior to enrollment * Smoker * Alcohol consumption greater than 2 drinks per day * Aerobic exercise greater than 5 hours per week * Pregnancy or fertility treatments * History of chronically active inflammatory or neoplastic disease in 3 years prior to enrollment * History of chronic gastrointestinal disorder including diarrhea, inflammatory bowel disease, celiac disease; coagulation disorders, chronic immunosuppressive medication usage * History of myocardial infarction or cerebrovascular accident within 6 months prior to participation