Evaluating the Safety and Efficacy of the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE for Treatment of Acute Pulmonary Embolism

Inclusion Criteria: * Signed and dated informed consent form. * 18 years of age and older. * Clinical signs and symptoms consistent with acute intermediate-risk pulmonary embolism for less than or equal to 14 days. * Diagnosis of pulmonary embolism detected from computed tomography angiography (CTA). * Right Ventricle to Left Ventricle (RV/LV) ratio of 0.9 or higher. * Systolic blood pressure (SBP) of 90 mmHg or higher * Heart rate of 130 beats per minute (BPM) or less prior to the procedure. * Deemed medically eligible for interventional procedure(s) per institutional guidelines and/or clinical judgment. Exclusion Criteria: Excluded from the study if he/she meets any of the following exclusion criteria * May be pregnant as determined by a positive pregnancy test or who are breastfeeding. * Has any contraindication to systemic or therapeutic doses of heparin or anticoagulants. * Has used thrombolytics (tPA) in the past 30 days of baseline CTA. * Has pulmonary hypertension with peak pulmonary artery pressure (PAP) \> 70 mmHg. * Fraction of inspired oxygen (FiO2) requirement \>40% or \>6 liters per minute (LPM) to keep oxygen saturations \>90% * Hematocrit \<28% within 6 hours of the index procedure. * Platelets count \< 100,000/µL. * Serum creatinine \>1.8 mg/dL. * International Normalized Ratio (INR) \> 3 * Has undergone a major trauma within the past 14 days of the index procedure and have Injury Severity Score (ISS) \> 15. * Presence of cancer requiring active chemother…