Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma

Exclusion criteria

• . Patients with non-endometrioid endometrial carcinoma, endometrioid endometrial carcinoma G2/G3 or other malignant tumors of the reproductive system; imaging suggests myometrial invasion, cervical involvement or extra-uterine involvement.
• . Combined with severe medical disease or liver or kidney dysfunction: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels elevate to 3 times or more of the upper limit of normal, kidney dysfunction (creatinine clearance \<30 mL/min)
• . Patients with other types of endometrial cancer or other malignant tumors of the reproductive system; patients with breast cancer or other hormone-dependent tumors that cannot be used with progesterone.
• . Those who have received high doses of high potency progestin or oral contraceptives within the last 3 months (or those on maintenance medication).
• . Those who require hysterectomy or other methods other than conservative treatment.
• . Known or suspected pregnancy.
• . Those who has contraindications to use progestin.
• . Deep vein thrombosis, stroke, myocardial infarction.