Effect of Subconjunctival 5-fluorouracil on the Outcome of Ahmed Valve in Neovascular Glaucoma (NCT05316142) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Effect of Subconjunctival 5-fluorouracil on the Outcome of Ahmed Valve in Neovascular Glaucoma
Iran70 participantsStarted 2024-05-01
Plain-language summary
Neovascular glaucoma is a common and severe type of secondary closed-angle glaucoma. Topical treatments have variable effects and unfortunately often require surgery to control IOP. Although Glaucoma Drainage Device (GDD) such as Ahmed Glaucoma Valve (AGV) are a surgical choice in these patients, their effectiveness decreases over time.
One of the main causes of failure in AGV surgery is the formation of scar tissue and fibrosis around the shunt plate.
So, the aim of this study was to evaluate the effect of using MMC Intraoperative and 5FU Postoperative with AGV surgery in neovascular glaucoma patients according to a specific protocol, on the incidence of Hypertensive Phase (HP) and surgical success rate.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
• Patients with diagnosis of neovascular glaucoma
Exclusion Criteria:
* Patients with no light perception
* Patients aged less than 18 years old
* History of previous GDD implantation
* History of cyclodestructive procedures
* Pregnant patients
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically for neovascular glaucoma treated with an Ahmed valve implant — is my situation a close enough match to make this study relevant to my care?
2The trial is looking at whether injecting 5-fluorouracil under the eye's surface improves the success rate of the Ahmed valve and reduces a complication called the 'hypertensive phase' — can you explain what the hypertensive phase is and how much of a problem it's been in patients like me?
3Since this trial is listed as 'active, not recruiting,' does that mean I can't join it, and if so, are there similar studies I could still be considered for?
4This trial doesn't have a traditional numbered phase, which can mean it's exploratory — what does that tell us about how much is already known about the safety and effectiveness of adding 5-fluorouracil to Ahmed valve surgery?
5Compared to getting an Ahmed valve implant on its own without the 5-fluorouracil injection, what would my doctor consider the standard approach for my stage of neovascular glaucoma, and how does this trial fit into that decision?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.