The Effects of Hydration on Gut Health and Thinking (NCT05315531) | Clinical Trial Compass
CompletedNot Applicable
The Effects of Hydration on Gut Health and Thinking
United States23 participantsStarted 2021-08-23
Plain-language summary
The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.
Who can participate
Age range
19 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* 19-50 years of age
* 18.5-34.49 kg/m2
* 24-hour UOsm above 500 mOsm/kg
* No antibiotic use over the past 3 months
* Absence of metabolic diseases and use of diuretics
* Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
* Avoid consuming prebiotic and probiotic supplements during study participation
* Not pregnant
* Agree to follow the study protocol
Exclusion Criteria:
* \<19 or \>50 years of age
* \<18.5 or \>34.49 kg/m2
* 24-hour UOsm \<500 mOsm/kg
* Antibiotic use over the past 3 months
* Metabolic diseases and use of diuretics
* Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
* intervention
* Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
* Pregnant
* Not agree to follow study protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.