Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy

Inclusion Criteria: * Aged between 18-35 years inclusive * Healthy, recreationally active (active for \>5 hours/ week) * Having given informed consent Exclusion Criteria: * Type I or Type II diabetes * Highly trained (active for \> 15 hours/week) * Lower limb and/or back injuries in the last 6 months * A history of thrombosis / cardiovascular disease * Use of anticoagulants * Musculoskeletal / orthopedic disorders * Use of tobacco products * Using medications known to modulate skeletal muscle metabolism including corticosteroids, hormone replacement therapy (HRT), non-steroidal anti-inflammatory drugs (i.e. paracetamol) and over-the-counter supplements including protein powder, creatine monohydrate, and fish oil * Pregnant * Currently participating in another clinical trial/ physical intervention research study