Active — Not RecruitingNot Applicable

The Effect of Violet Device Dosed Ultra Violet-C Light (UV-C) Exposure on Healthy Hand Skin

United States30 participantsStarted 2022-04-19

Plain-language summary

The purpose of this trial is to determine the safety of ultraviolet light (UV-C) irradiation as a method to sanitize hands instead of chemical-based sanitizers. Eligible participants will be enrolled and receive treatment with the Violet UV-C device or UV-B. Punch biopsies will be performed following UV exposure to quantify any changes in cellular and molecular properties of the tissue.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion Criteria * Good general health * Type 1 or type 2 skin (lightly colored skin) * No history of skin disorders, disease states or physical conditions which would impair evaluation of the test sites * Willingness and ability to follow the protocol * No use of lotion or hand sanitizer 3 hours before the experiment Exclusion Criteria: * Has received an experimental drug or used an experimental device in the 30 days prior to admission to the study * Undergoing treatment or taking medication that increases sun sensitivity * History of keloids * History of sensitivity to lidocaine or epinephrine * Pregnant or nursing women, pregnancy status will be self-reported, women unsure of their pregnancy status will be excluded

What they're measuring

Deoxyribonucleic acid (DNA) damage in the form of DNA base pair dimers measured by immunohistochemistry microscopy with statistical analysis.

Timeframe: Day 1 (visit 1 after light therapy)

Trial details

NCT IDNCT05313555

SponsorUniversity of Michigan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09

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