KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs

Inclusion Criteria: * Age: 18-65 years old * Chronic migraine, diagnosed according to ICHD-3 criteria. * Patients with resistant form of migraine defined as: persistence of 8 days of headache per month; therapeutic failure (after therapeutic treatment of adequate dose and duration) or contraindication of 3 classes of drugs with validated evidence of efficacy in the prevention of migraine. * Non-responder (absence of reduction of MIDAS score of at least 50% after at least 3 months of treatment) to at least one anti-CGRP monoclonal antibody * Absence of prophylactic therapies for migraine or prophylaxis therapy with a single drug taken at a stable dose for at least two months * BMI \> 16.5 kg/m2 and \< 35 kg/m2 * Hypothesized compliance in filling the headache diary and following the prescribed diet Exclusion Criteria: * Kidney failure * Liver failure * Heart failure * Recent heart attack * Pancreatitis * Alcoholism * Severe osteoporosis * Other neurological disorders, including other forms of primary headache, except sporadic episodic tension-type headache * Diabetes Mellitus * Severe lipid metabolism disorders * Women of childbearing age without active contraception * Pregnancy or breastfeeding * Psychiatric disorders that the clinician thinks may interfere with patient compliance / eating disorders * Other anomalies considered significant in preliminary examinations (blood tests and EKG)