CompletedNot Applicable

An RCT of NBI vs. White Light Guided Endobronchial Biopsy in Suspected Sarcoidosis

India150 participantsStarted 2022-01-01

Plain-language summary

In the diagnosis of patients with sarcoidosis, there is paucity of literature on the diagnostic yield of the endobronchial biopsies obtained with narrow band imaging (NBI) bronchoscopy. The present study aims to compare the diagnostic yield of endobronchial biopsyperformed under direct narrow band imaging or white light bronchoscopy guidance in suspected sarcoidosis.We hypothesize that the use of NBI will improve the yield of endobronchial biopsy in patients with sarcoidosis.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age more than 18 years.
✓. Clinical presentation and radiological findings (enlarged hilar and or mediastinal lymph nodes \>10 mm \[short axis\], and/or perilymphatic nodules or peribronchovascular thickening on computed tomography \[CT\] chest) suggesting sarcoidosis.
✓. Willing to give informed consent.

Exclusion criteria

✕. Hemodynamic instability (systolic BP \<100 mm Hg).
✕. Pregnancy.
✕. Treatment with systemic glucocorticoids for more than three weeks in the preceding three months.
✕. Diagnosis of sarcoidosis possible with another minimally invasive technique such as skin biopsy or peripheral lymph node biopsy.

What they're measuring

Yield of granulomatous inflammation in endobronchial biopsy in subjects with a final diagnosis of sarcoidosis

Timeframe: 7 days

Trial details

NCT IDNCT05311150

SponsorPost Graduate Institute of Medical Education and Research, Chandigarh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-31

View on ClinicalTrials.gov More Sarcoidosis, Pulmonary trials