Precision Medicine Approach to Unravel the Risk Factors for Renal, Cardiovascular, Ophthalmologic, Neurologic and Hepatic Complications of Metabolic Disorders

Inclusion Criteria: * Adult persons, male or female, age ≥ 18 and ≤ 65 years * Persons able to understand the information provided and to object to it (at the discretion of the investigator) * Patient affiliated to a social security system. * Patient willing to sign an informed consent form * Patient with the following metabolic profile Diabetic (of any type) treated or not (diabetes will be defined by a fasting blood glucose \> 7mM or a HbA1c \> 6.5% or by the use of an antidiabetic treatment) AND/OR Obese patient (BMI \> 30 kg/m2) treated or not * Patient with evidence of renal parenchymal damage defined by an albuminuria/creatinuria ratio ≥ 3 mg/mmol (30mg/g), AND/OR a glomerular filtration rate estimated by the CKD-EPI (eDFG) formula classifying the patient as stage 2 to 3a of the KDIGO classification (i.e., 90ml/min/1.73 m2 \> GFR \> 45ml/min), AND/OR a renal lithiasis Exclusion Criteria: * Patient deprived of liberty * Person subject to a legal protection measure (guardianship, curatorship or safeguard of justice) * Patient refusing to participate in the study * Pregnant, parturient or nursing woman * Patient in emergency situation * Patient with advanced chronic kidney disease defined as GFR \< 45ml/min/1.73 m². * Contraindication to Iohexol injection * Patient with or who has had any of the following complications: symptomatic coronary artery disease, symptomatic peripheral arterial disease, previous stroke, previous myocardial infarction, heart failure ≥ stage B, …