Restrictive Versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury (NCT05306964) | Clinical Trial Compass
TerminatedNot Applicable
Restrictive Versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury
Stopped: The trial was terminated due to insufficient funds.
United States99 participantsStarted 2022-07-05
Plain-language summary
Critically ill patients with acute kidney injury and fluid overload who are frequently treated by fluid removal during dialysis are at an increased risk of complications and death. Both slower and faster rates of fluid removal may cause injury to the vital organs. This proposed clinical trial will examine the feasibility of restrictive compared with a liberal rate of fluid removal in order to develop effective treatments for fluid overload and to improve the health of critically ill patients.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age 18 years or older
✓. Stage 3 acute kidney injury according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria
✓. Started or intending to start CKRT for volume management
✓. Attending intensivist or nephrologist intending to remove net fluid using CKRT for at least 48 hours
Exclusion criteria
✕. Respiratory distress due to pulmonary edema or fluid overload in unintubated patients
✕. Massive volume infusion (i.e., \>200 mL/h for \>6 hours of continuous infusion)
✕. No intention to remove net fluid as determined by attending intensivist or nephrologist
✕. Attending intensivist or nephrologist believes that the protocol will not be followed
✕. Continuous net fluid removal for \>48 hours prior to study enrollment
✕
What they're measuring
1
Delivered UFnet Rates.
Timeframe: Until the end of continuous kidney replacement therapy or day 28, whichever occurs first.
2
No. of Participants With Protocol Deviation.
Timeframe: Until the end of continuous kidney replacement therapy or day 28, whichever occurs first.