Treatment of Monosymptomatic Nocturnal Enuresis

Inclusion Criteria: * All subjects were diagnosed as patients with MNE according to the Diagnostic and statistical manual of mental disorders, 4th revised edition (DSM-IV) (American Psychiatric Association's DSM-IV, 1994): bed-wetting ≥3 times a week; lasting more than 6 months; can control urination during the day but cannot control urination after falling asleep. Exclusion Criteria: * \- Patients younger than 5 years old. * Patients who have any abnormality in blood or urine biochemistry. * Patients with other urinary symptoms. * Patients with neurological or endocrinal abnormalities (such as cerebral palsy, spinal cord lesion, peripheral neuropathy or diabetes mellitus)