UnknownPhase 1/2

Stem Cells and Stromal Vascular Fraction for Temporomandibular Joint Disease

Turkey (Türkiye)20 participantsStarted 2021-10-01

Plain-language summary

It will be evaluate the safety of mesenchymal stem cells and adipose tissue derived stromal vascular fraction (SVF) in temporomandibular joint disease cases.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Chronic temporomandibular arthritic disorder * History of pain and joint noises for at least 3 months * Must have more than VAS 5 TMJ pain * must have internal derangement of TMJ * Limited mouth opening * Magnetic resonance imaging evidence of effusion or degeneration * Already treated with conservative methods (occlusal splint,pharmacological and/or physio-kinesio therapy) without satisfactory benefit. Exclusion Criteria: * Cancer patients * Immunosupressed patients * Previous TMJ traumas and fractures * Previous TMJ surgeries * TMJ ankylosis

What they're measuring

Change from Baseline Pain at 15th day

Timeframe: 15th day

Change from baseline maximum mouth opening at 15th day

Timeframe: 15th day

Change from baseline maximum mouth opening at 1 month

Timeframe: 1. month

Change from baseline maximum mouth opening at 3 months

Timeframe: 3. month

Change from baseline maximum mouth opening at 6 months

Timeframe: 6. month

Change from baseline pain at 1 month

Timeframe: 1. month

Change from baseline pain at 3 month

Timeframe: 3. month

Change from baseline pain at 6 month

Timeframe: 6. month

Trial details

NCT IDNCT05305833

SponsorTC Erciyes University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-01

Contact for this trial

Zeynep B Gonen, DDS,PHD

00903522076666 zburcin@gmail.com

View on ClinicalTrials.gov More Temporomandibular Joint Disorders trials