CompletedNot Applicable

NA-AION Risk Factors: New Perspectives

United States179 participantsStarted 2021-08-01

Plain-language summary

The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with anatomical and vascular characteristics of the optic nerve.

Who can participate

Age range11 Years

SexALL

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Inclusion criteria

✓. Diagnosis of first episode of NA-AION in study eye with symptom onset within 1 month prior
✓. Subject age: Age \>10
✓. NA-AION diagnosis requires:

Exclusion criteria

✕. Previous episode of NA-AION in the study eye only
✕. Intraocular pressure of \>21 mm Hg in the study eye
✕. Clinical or pathological evidence of giant cell arteritis
✕. Diseases that may affect the optic nerve: glaucoma, multiple sclerosis, Alzheimer disease, and Parkinson disease. Evidence of optic disc drusen and optic nerve hypoplasia are not exclusion criteria given they are important parts of the study. We will not exclude significant retinal diseases, since they may be related to underlying etiologies giving rise to ODD, such as macular degeneration, retinal dystrophies, but eyes with significant retinal diseases will be analyzed separately.

What they're measuring

Anatomical characteristics on OCT

Timeframe: At enrollment

Anatomical characteristics on OCT

Timeframe: 3-months follow-up visit

Vascular characteristics on OCT-A

Timeframe: 3-months follow-up visit

Trial details

NCT IDNCT05305079

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-31

View on ClinicalTrials.gov More Non-arteritic Ischemic Optic Neuropathy trials