The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI). The primary aim of this study is to compare putative 'chronic' EHI risk factors between a cohort who have suffered a history of EHI and a control cohort with no EHI history. The secondary aim is to examine the influence of these EHI risk factors on thermoregulation during a standard heat tolerance assessment.
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Core temperature
Timeframe: At 60 minutes (or test termination if earlier) of Heat Tolerance Assessment
Core temperature
Timeframe: Rate of rise from 30 to 60 minutes (or test termination if earlier) of Heat Tolerance Assessment
Diversity of gastrointestinal microbiota
Timeframe: Baseline
Diversity of gastrointestinal microbiota
Timeframe: Baseline
Abundance of gastrointestinal microbiota
Timeframe: Baseline
Detection of sexually transmitted pathogens
Timeframe: Baseline
Detection of respiratory pathogens
Timeframe: Baseline
Detection of gastrointestinal pathogens
Timeframe: Baseline
Circulating Interleukin 6
Timeframe: Baseline
Circulating Interleukin 6
Timeframe: Post Heat Tolerance Assessment (within 15 minutes of test end)
Circulating C-Reactive Protein
Timeframe: Baseline
Circulating C-Reactive Protein
Timeframe: Post Heat Tolerance Assessment (within 15 minutes of test end)
Circulating Claudin 3
Timeframe: Baseline
Circulating Claudin 3
Timeframe: Post Heat Tolerance Assessment (within 15 minutes of test end)
Circulating Zonulin
Timeframe: Baseline
Circulating lipopolysaccharide binding protein
Timeframe: Baseline
Circulating lipopolysaccharide binding protein
Timeframe: Post Heat Tolerance Assessment (within 15 minutes of test end)
Circulating intestinal fatty acid binding protein
Timeframe: Baseline
Circulating intestinal fatty acid binding protein
Timeframe: Post Heat Tolerance Assessment (within 15 minutes of test end)
Gastrointestinal illness symptomology questionnaire
Timeframe: Baseline
Gastrointestinal illness symptomology questionnaire
Timeframe: Pre Heat Tolerance Assessment
Gastrointestinal illness symptomology questionnaire
Timeframe: Immediately post Heat Tolerance Assessment
Respiratory illness symptomology, measured by Jackson common cold questionnaire
Timeframe: Baseline
Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index
Timeframe: Baseline -3 days
Motivation, measured by Motivation scale
Timeframe: Baseline -3 days
State-trait anxiety, measured by state-trait anxiety inventory form Y-2
Timeframe: Baseline -3 days
Risk taking, measured by the risk-taking inventory
Timeframe: Baseline -3 days
Resilience, measured by the Connor-Davidson resilience scale
Timeframe: Baseline -3 days
Stress, measured by perceived stress scale
Timeframe: Baseline -3 days
Mental readiness
Timeframe: Baseline
Stress
Timeframe: Baseline