CompletedNot Applicable

Preoperative Administration of Oral Carbohydrate Drink, Neutrophil/Lymphocyte Ratio and Postoperative Complications

Bosnia and Herzegovina60 participantsStarted 2020-05-04

Plain-language summary

This study evaluated the impact of a preoperative carbohydrate oral drink on the postoperative Neutrophil / Lymphocyte Ratio (NLR) and the incidence of postoperative complications after elective open colon surgery compared to the conventional preoperative fasting protocol. Hypothesis was: preoperative carbohydrate loading reduces postoperative NLR value and reduces the incidence and severity of postoperative complications in colorectal surgery.

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * participants with diagnosed colorectal carcinoma scheduled for elective open colorectal surgery * aged between 18 years and 70 years * participants with ASA physical status class I-III Exclusion Criteria: * previous treatment of colon, rectum or any other cancer * emergency or palliative colon and rectum surgery * disseminated malignant disease * body mass index below 20 and above 30 kg/mᶺ2 * overall score ≥3 after final assessment of the nutritional status according to Nutritional Risk Screening 2002 (NRS-2002) * disease with increased risk of aspiration * history of diabetes mellitus * history of hematological disease * evidence of systemic inflammation * immunomodulatory therapy * neuromuscular disease * pregnancy * mental disease * allergy to any study drugs * alcoholic or drug abuse * patient's refusal to participate in the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The mean change in NLR values between conventional preoperative fasting protocol and a preoperative carbohydrate loading

Timeframe: fasting peripheral venous blood samples were collected at 06:00 am on the day of surgery (basal value), at 06:00 am on the first postoperative day, at 06:00 am on the third postoperative day and at 06:00 am on the fifth postoperative day.

The mean change in delta NLR value between conventional preoperative fasting protocol and a preoperative carbohydrate loading

Trial details

NCT IDNCT05301985

SponsorNermina Rizvanović

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-20

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