RecruitingNot Applicable

Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations

United States104 participantsStarted 2022-03-01

Plain-language summary

Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.

Who can participate

Age range18 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients diagnosed with SZ or schizoaffective disorder using DSM-5 criteria * auditory hallucinations not responsive to pharmacology as determined by chart review and a clinical interview of SCID. Exclusion Criteria: * neurologic illness * major head trauma * electroconvulsive therapy * alcohol or drug dependence * alcohol or drug abuse within the past five years * verbal IQ below 70

What they're measuring

percent change in the STG BOLD signal, post- relative to pre-NFB

Timeframe: 0-4 weeks post intervention

Trial details

NCT IDNCT05299749

SponsorBoston VA Research Institute, Inc.

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

Contact for this trial

margaret niznikiewicz, PhD

6176534627 margaret_niznikiewicz@hms.harvard.edu

View on ClinicalTrials.gov More Schizophrenia trials