TerminatedNot Applicable

Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)

Stopped: The study was determined to not be feasible at this time.

United States5 participantsStarted 2023-06-15

Plain-language summary

The goal is to characterize vascular reactivity and cardiac pulsatility of normal appearing white matter in patients with CCM during hypercarbia/hypocarbia using quantitative real-time high-speed multi-echo fMRI to develop prognostic biomarkers for CCM formation

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. All familial CCM subjects presenting at UNMH who can consent to our study.
✓. Adult Male/Female patients ages \>18 years old

Exclusion criteria

✕. Individuals ages \<18 year
✕. Subjects with a known fear of dyspnea or enclosed spaces will be excluded from this study as well as those with metal implants, COPD, heart conditions, and hypercapnia.
✕. Subjects who have contraindications to MRI such as harboring incompatible ferromagnetic objects implanted in the body.
✕. Pregnant women (screening for pregnancy will be performed by oral questionnaire. MRI is safe in pregnancy but the study will exclude pregnant subjects, as the effects of respiratory challenge cannot be predicted in such subjects. Since these effects are proportional to the stage of gestation, oral history will be sufficient to assure safety.)
✕. Prisoners.
✕. People unable to consent.
✕. People unable to participate due to prior neurological deficits.
✕. Subjects with underlying pre-existing pulmonary illness; such as asthma, COPD, pulmonary hypertension, will be excluded.

What they're measuring

Hemodynamic Response

Timeframe: 12 Months

Resting state connectivity

Timeframe: 12 month

Trial details

NCT IDNCT05298709

SponsorUniversity of New Mexico

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-17

View on ClinicalTrials.gov More Cerebral Cavernous Malformation trials