Pathophysiologic Study to Understand and Possibly Treat Nocturia

Inclusion Criteria: * Age above or equal to 18 years at the time of signing informed consent * Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures * Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study prior to initiation of any protocol-mandated procedures. Exclusion Criteria: * Suspected or proven peripheral arterial disease, including history of peripheral arterial bypass grafting * Any sensory impairment such as severe peripheral neuropathy as evidenced by patient reported intermittent claudication and/or signs of ischemia such as "blue toes". * Allergy to stocking textile material. * Leg edema or pulmonary edema from congestive heart failure. * Local skin or soft-tissue condition, including recent skin graft, gangrene, oozing dermatitis and severe cellulitis. * Extreme deformity of the leg, or unusual leg shape or size that would prevent correct fit. * Treatment with any diuretics such as furosemide or hydrochlorothiazide.