UnknownNot Applicable

Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure

Tunisia600 participantsStarted 2018-07-01

Plain-language summary

Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure (ADHF).However, chronic treatment with diuretics may limit their response and deteriorates the renal function. The hypertonic saline solution (HSS) has been proposed in recent years as an adjunctive therapy for intravenous loop diuretics to improve or restore their initial pharmacological efficacy. In this study the investigators will evaluate the effectiveness of HSS as an adjunct to i.v. furosemide in patients admitted for AHF with renal dysfunction

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with 18 years of age or older * ADHF with congestive symptoms, laboratory(BNP) and echocardiographic criteria * NYHA ≥II(New York Heart Association functional classification) * Creatinine clearance≤60ml/mn (MDRD) or level of creatinine \>150 µg/ml) * BNP levels on admission ≥400 pg/mL Exclusion Criteria: * age \< 18 years * NYHA class \< II * Patients with acute coronary syndrome, pulmonary thromboembolism, cardiac tamponade, pericarditis, those on dialysis; patients with chronic liver disease, pleuropneumonia, cerebral vascular disease, cancer, uncompensated diabetes, patients requiring pacemaker and concomitant other important comorbidity * Signs of hemodynamic instability, respiratory distress, coma

What they're measuring

Length of Hospital Stay

Timeframe: 1 week

In-hospital mortality

Timeframe: 1 week

Renal Function Impairement

Timeframe: 1 week

Need for inotropic drugs

Timeframe: 1 week

Trial details

NCT IDNCT05298098

SponsorUniversity of Monastir

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09

Contact for this trial

Semir Nouira, Professor

73106046 semir.nouira@rns.tn

View on ClinicalTrials.gov More Acute Decompensated Heart Failure trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.