Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material

Inclusion Criteria: * Age greater than or equal to 14 years. * Stable fracture, even if unconsolidated. * Controlled infection (absence of signs or symptoms of sepsis). * Early or delayed infection. * Availability of antibiotics active against the isolated microorganism. * Absence of bone exposure. Patients who initially had bone exposure but during the debridement surgery bone coverage was performed by any method (skin approximation, grafting, vacuum therapy) can be included in the criteria. * Signed written informed consent. * If there is a possibility of pregnancy (in women of childbearing potential) or paternity, agree to use a highly effective method of birth control recommended by the Clinical Trial Facilitation Group (CTFG) during the treatment phase of the trial Exclusion Criteria: * Late infections * Infections of osteosynthesis material in non-long bones. * Infections of revision osteosynthesis material or occurring after previous surgeries. * Patients who are not expected to be followed up for at least 1 year after completion of antibiotic treatment. * Pregnant or lactating women. * Patients in whom there may be drug interactions or contraindications described in the technical data sheets of the investigational drugs used in this trial. * Infections due to mycobacteria, fungi and parasites (since they are infections that are treated with drugs and for different durations). * Patients in whom all the material is replaced during the debridement at the same surgica…