Not Yet RecruitingNot Applicable

Are Mast Cells Involved in Autoinflammatory Diseases

France590 participantsStarted 2022-03

Plain-language summary

Autoinflammatory diseases (AID) are caused by innate immunity dysregulation. AID pathophysiology is only partly understood, especially in the case of unclassified AID. Mast cells (MC) are innate immune cells associated with a spectrum of disease between systemic mastocytosis and mast cell activation syndrome. The implication of MC has been shown in cryopyrin associated periodic syndrome (CAPS).Our aim is to evaluate the involvement of MC in AID by assessing clinical and biological signs of MC activation and studying cutaneous and digestive biopsies.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients \>18 years old with Auto-inflammatory diseases already followed up at the CeRéMAIA (french national reference center for autoinflamamtory diseases and AA amyloidosis) of Tenon hospital and included in the JIRcohorte * Healthy adult controls, age- and sex-matched with MAI patients, and controls with mastocytosis, an immuno-inflammatory disease. * Subject affiliated to or entitled to a social security scheme * Collection of the patient's or healthy control's non-opposition Exclusion Criteria: * Subjects unable to answer questions or express themselves * Subjects who do not speak French * Subject deprived of liberty or under legal protection.

What they're measuring

: presence of MCAS

Timeframe: at inclusion

Trial details

NCT IDNCT05292768

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-10

Contact for this trial

Sophie GEORGIN-LAVIALLE, PU-PH

+33 (0)1 56 01 72 04 or 60 77 sophie.georgin-lavialle@aphp.fr

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