Intrarenal Microvasculature in ADPKD

Inclusion Criteria (Patients with ADPKD): * Male and female subjects 18 - 40 years of age, inclusive * Previous diagnosis of ADPKD (based on Ravine et al. criteria) * Class 1 according to imaging classification * Estimated GFR\> 90 mL/min/m2 (CKD-Epi equation) * Ability to provide written, informed consent Inclusion Criteria (Healthy Volunteers): * Male and female subjects 18 - 40 years of age, inclusive * Estimated GFR\> 90 mL/min/m2 (CKD-Epi equation) * Ability to provide written, informed consent Exclusion Criteria (Patients with ADPKD): * Class 2 according to imaging classification * A concomitant systemic disease affecting the kidney (e.g., lupus, hepatitis B or C, amyloidosis) * Diabetes mellitus (fasting glucose \> 126 mg/dL or treatment with insulin or oral hypoglycemics). * Predicted urine protein excretion in urinalysis \>1 g/24 hrs. * Subjects having contraindications to or interference with MRI assessments. \[For example ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc.\]. * History of hypersensitivity allergic reactions to ultrasound contrast agents * High-risk cardiac disease (such as unstable hospital in-patients or ICU patients * Patients that are part of an interventional study or are taking tolvaptan * Female subjects that are pregnant Exclusion Criteria (Healthy Volunteers): * Family and/or personal history of kidney disease * Concomitant systemic disease that may affect the kidney * Diabetes me…