CompletedNot Applicable

Feasibility of Exosome Analysis in Cerebrospinal Fluid During the Diagnostic Workup of Metastatic Meningitis

France7 participantsStarted 2023-01-04

Plain-language summary

The investigators are interested in one of the most frequent tumor types causing leptomeningeal metastasis in order to investigate whether a profile can be established by a high-throughput clinical proteomic approach. All the data acquired will allow a tailored and promising approach to improve the knowledge of metastatic tumor meningitis.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient with histologically proven breast cancer; * Patient with suspected metastatic leptomeningeal involvement; * Age ≥ 18 ans ; * WHO performance status ≤ 2 ; * Affiliation to the National Social Security System ; * With informed and signed consent Exclusion Criteria: * History of another cancer than the one for which the patient is referred; * Contraindication to lumbar puncture or cerebrospinal MRI * Pregnant or breastfeeding woman

What they're measuring

CSF protein composition

Timeframe: 36 months

cytological analysis of the CSF

Timeframe: 36 months

Trial details

NCT IDNCT05286684

SponsorCentre Oscar Lambret

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-11-15

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