Early Prediction of ICD Candidacy After Anterior Myocardial Infarction (NCT05285631) | Clinical Trial Compass
CompletedNot Applicable
Early Prediction of ICD Candidacy After Anterior Myocardial Infarction
Egypt200 participantsStarted 2022-05-31
Plain-language summary
Despite the advances of pharmacologic and interventional therapies, sudden (or arrhythmic) cardiac death remains very high in the early weeks-to-months after an acute myocardial infarction (MI).The majority of cardiac arrests occur in patients who have large infarctions resulting in extensive myocardial damage, which is translated into lower left ventricular ejection fraction (LVEF). Hence, low LVEF remains -to the current time- the most robust predictor for post MI sudden (and presumably arrhythmic) death; and is the determinant for implantable cardioverter defibrillator (ICD) candidacy for primary prevention as per clinical practice guidelines.ICD significantly and effectively reduced ventricular arrhythmia (VA)-mediated cardiac deaths among these patients.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 80 years. Both genders are eligible.
* Patients with diagnosis of an acute anterior STEMI and revascularized with successful primary percutaneous coronary intervention (PCI) within 24 hours.
* LVEF \< 40 % assessed by Bi-plane Simpsons rule within 48 hour post PCI.
Exclusion Criteria:
* ● Refusal to participate in the study.
* Patients with existing ICD or pacemakers.
* Qualifying ICD for secondary prevention.
* Known to have LVEF ≤ 40% prior to the index MI.
* Previous PCI to Left anterior Descending artery (LAD).
* Previous or being scheduled for CABG within ≤ 3 months.
* Known to have limited life expectancy (less than 1-year) prior to the index MI.
* Pregnant or lactating women.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used speckle tracking echocardiography to predict which anterior STEMI patients might need an ICD — has my heart function been assessed using this technique, and what did it show about my risk?
2Since this study focused specifically on anterior heart attacks (anterior STEMI), and I've had an anterior MI, does my doctor think the findings from this research are relevant to deciding whether I need an ICD?
3This trial is already completed — does my doctor know if the results have been published, and if so, do those results suggest any early warning signs in my case that we should be watching for?
4Because this was a prediction study rather than a treatment trial, it wasn't testing a new drug or device on patients — so should I be asking separately about what the current standard criteria are for recommending an ICD after a heart attack like mine?
5Given that this research was trying to catch ICD candidacy early after a heart attack, is there a window of time after my MI where getting this type of echocardiogram would still be meaningful, and should we be scheduling one soon?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Early prediction of ICD candidacy in anterior STEMI patients by speckle tracking echocardiography