The circadian rhythm characteristics of sleep cycle and neuroendocrine in patients with chronic disorder of consciousness show different degrees of disorder, and the relationship between this disorder and consciousness level is unclear.The researchers used HD-tDCS to treat patients with chronic disturbance of consciousness who intervened in circadian rhythm, and used a variety of methods such as EEG, fMRI, protein metabolism, ERP and micro-expression to explore the mechanism of improving the state of consciousness of HD-DCS and the relationship between circadian rhythm and patients' consciousness level
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The Coma Recovery Scale-Revised (CRS-R) scale
Timeframe: Change from Baseline CRS-R at 14 days.
Electroencephalography (EEG)
Timeframe: Change from baseline EEG power spectral density at 14 days.
Sleep parameters
Timeframe: Change from baseline sleep patterns at 14 days.
Resting state fMRI
Timeframe: Change from ReHo, ALFF, fALFF and functional connectivity at 14 days.
Micro-expression
Timeframe: At baseline.