Active — Not RecruitingPhase 3

Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease

Egypt80 participantsStarted 2022-01-08

Plain-language summary

The aim of this study is to evaluate the effect of administration of folic acid and /or pentoxifylline on patients with chronic kidney disease (CKD).

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patients who have chronic kidney disease(CKD) stages 3-5
✓. Aged between18 - 60 years old.
✓. Both sexes.
✓. Stable clinical condition defined as no hospitalizations or cardiovascular events within the 3 months before screening
✓. Stable renal function (baseline serum creatinine had to have not increased by 50% in the 3 months before screening)
✓. No changes in concomitant medication during the study.
✓. Patients who accept to participate in the study.

✕. Pregnant women
✕. Current use of PTF
✕. Contraindication to use of PTF drug: history of PTF or theophylline allergy, history of severe retinal hemorrhage or recent cerebral hemorrhage
✕. Those with active infections or inflammatory diseases or HIV infection
✕. Those with chronic liver disease .
✕. Patients who had received immunosuppressive therapy
✕. Non-compliant patients

Change in Serum Creatinine Level

Timeframe: Baseline, 6 months

NCT IDNCT05284656

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-12

Results submitted2023-06-21