Active — Not RecruitingNot Applicable

Sickle Cell Disease (SCD) Bone Pain Study

United States53 participantsStarted 2022-11-03

Plain-language summary

A prospective study to determine how low bone mineral density and/or vertebral compression fractures associate with pain in adults with sickle cell disease

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography) * Ability to provide written informed consent * Ability to lay on a DXA scanner * Negative urine pregnancy test for women of childbearing potential at study entry Exclusion Criteria: * Pregnant women * Adults unable to consent * Individuals who are not yet adults (infants, children, teenagers) * Prisoners * Hospitalizations (any cause) within 2 weeks of study entry

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Lumbar Spine Bone Mineral Density

Timeframe: Baseline

Lumbar Spine Bone Mineral Density-Z-scores

Timeframe: Baseline

Total Hip Bone Mineral Density (BMD)

Timeframe: Baseline

Total Hip Bone Mineral Density-Z-scores

Timeframe: At enrollment

Femoral Neck Bone Mineral Density (BMD)

Timeframe: Baseline

Femoral Neck Bone Mineral Density Z-scores

Timeframe: Baseline

Adult Sickle Cell Quality of Life Measurement System (ASCQ-Me) Pain Impact T-scores

Timeframe: Baseline

Trial details

NCT IDNCT05283148

SponsorUniversity of California, Davis

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-30

Results submitted2025-04-01

View on ClinicalTrials.gov More Sickle Cell Disease trials

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Lumbar Spine Bone Mineral Density

Timeframe: Baseline

Lumbar Spine Bone Mineral Density-Z-scores

Timeframe: Baseline

Total Hip Bone Mineral Density (BMD)

Timeframe: Baseline

Total Hip Bone Mineral Density-Z-scores

Timeframe: At enrollment

Femoral Neck Bone Mineral Density (BMD)

Timeframe: Baseline

Femoral Neck Bone Mineral Density Z-scores

Timeframe: Baseline

Adult Sickle Cell Quality of Life Measurement System (ASCQ-Me) Pain Impact T-scores

Timeframe: Baseline