CompletedNot Applicable

The Water Drinking Test in Glaucoma Study

United Kingdom46 participantsStarted 2021-03-17

Plain-language summary

To investigate the correlation and agreement between the intraocular pressure peaks detected during the water drinking test and modified diurnal tension curve in glaucomatous eyes and to analyse whether this is associated with prognostic outcome. The study will also measure autonomic nervous system activation during the test to investigate one possible mechanism behind it.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Able to give informed consent to participate in the study * Aged between 18 and 80 years of age * Clear optical media * Spherical equivalent +-10 Dioptres * Normal tension glaucoma proven by visual field testing or OCT imaging combined with clinical assessment. * Primary open angle glaucoma proven by visual field testing or OCT imaging combined with clinical assessment. Exclusion Criteria: * Are using ocular hypotensive therapy, or have done so in the last 30 days * Have any other known ocular disease (except glaucoma) * Have serious cardiac or kidney disease (WDT contra-indication) * Have swallowing difficulties associated with either a neurological or gastrointestinal condition. * Patients with any contra-indication of drinking large amounts of water in a small period of time e.g. swallowing impairment, oesophageal stricture, gastric banding. * Have secondary or narrow/closed angle glaucoma * Patients submitted to any surgical procedure or laser intervention during the evaluation period

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Maximum Intraocular Pressure Difference (Between mDCT and WDT)

Timeframe: Single measurement (mDCT 5 measurements taken one every 2 hours and WDT a measurement taken every 15 minutes up to 45 minutes)

Trial details

NCT IDNCT05283031

SponsorImperial College London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-06-09

Results submitted2022-08-12

View on ClinicalTrials.gov More Glaucoma trials