Evaluation of Micro-osteoperforations to Accelerate Orthodontic Tooth Movement

Inclusion Criteria: * both male and female subjects * 16 or more years old * orthodontic need of upper incisors extractions * presence of all upper permanent teeth with exception of the third molars. Exclusion Criteria: * diseases and medications that were likely to affect bone biology * pregnancy * poor oral hygiene * previous orthodontic treatment * evidence of bone loss * active periodontal disease * smoking * syndromes or cleft patients * severe crowding or Class II malocclusion (Pg-Nper \> 18 mm, ANB \> 7º, SN-GoGn \> 38º e overjet \> 10 mm).