Stopped: Low enrollment of participants
The purpose of this study is to determine whether tart cherry supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I. To determine if tart cherry in combination with repeated bouts of thermally stressful exercise will impact the gut microbiome \& inflammation measured via stool sample \& blood samples for plasma endotoxin, inflammatory cytokines and HSP. Specific Aim II. To determine whether whole body hyperthermia causes changes in bacterial populations in the gut microbiome, and if these changes are affected by washout or re-acclimation. Specific Aim III. To determine whether tart cherry supplementation suppresses the ability of human subjects to acclimate to exercise/heat stress. This will be assessed via body temperature, heart rate, sweat and plasma volume responses, and exercise performance during standardized heat tolerance tests.
Age range
18 Years – 55 Years
Sex
MALE
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Plasma TNF-a
Timeframe: pre, 1 hour post heat tolerance test
Change in Plasma IL-6
Timeframe: pre, 1 hour post heat tolerance test
Change in Plasma HSP70
Timeframe: pre, 1 hour post heat tolerance test
Change in Plasma melatonin content
Timeframe: pre- heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in Core temperature response to heat tolerance test
Timeframe: heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in Skin temperature response to heat tolerance test
Timeframe: heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in Mean body temperature response to heat tolerance test
Timeframe: heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in Heart rate response to heat tolerance test
Timeframe: heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in Physiological strain response to heat tolerance test
Timeframe: heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)
Change in gut microbial content
Timeframe: pre- heat tolerance test 1 (before study onset) and 2 (day 6 of exercise/heat stress)