Assessment of Reward Responses to Erythritol Using Flavor Preference Learning (NCT05279183) | Clinical Trial Compass
CompletedNot Applicable
Assessment of Reward Responses to Erythritol Using Flavor Preference Learning
Switzerland20 participantsStarted 2022-03-17
Plain-language summary
The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants. In addition, the release of GI hormones, glycemic control, appetite-related sensations, and emotional state in response to erythritol will be investigated.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy normal weight participants with a body-mass index (BMI) of 19.0-24.9 kg/m2
* Age 18-55 years
* Stable body weight (±5%) for at least three months
* Able to give informed consent as documented by signature
* 3 drinks rated as neutral and novel (from the flavor preference learning)
Exclusion Criteria:
* Non-taster (deficits of taste and smell) or supertaster
* Fructose intolerance
* Shift worker
* Pre-existing regular consumption of erythritol and/or sucralose and/or aspartame (\>1/week)
* Substance abuse (more than 1 glass wine/beer per day; consumption of cannabis, cocaine, heroin, etc.)
* Regular intake of medications, except contraceptives
* Chronic or clinically relevant acute infections
* Pregnancy: although no contraindication, pregnancy might influence metabolic state.
* Participation in another study with investigational drug within the 30 days preceding and during the present study
* Pre-existing diet (vegetarian, vegan, sugar free)
* Inability to follow procedures due to psychological disorders or insufficient knowledge of project language (German)
* Calculated dose of erythritol outside the range of 30-60g (per 300mL) (from the sweetness matching)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Assessment of the change of explicit wanting (reward response) to oral erythritol versus sucrose and sucralose as change from baseline to post-test visit.
Timeframe: from baseline to post-test visit (at t = 0min, t = 45min and t = 90min)