Comparing Arrow PICC Catheters w/ Arrowga+rd Blue Advanced Protection Performance and Safety to Unprotected PICC's

Inclusion Criteria: * Patients age ≥ 18 years requiring a PICC * Patient will remain an inpatient for the entire dwell time * Ability to comply with study requirements of duplex ultrasound procedures prior to and at the time of PICC removal * Patients cognitively and physically able to give written consent to participate in the study or patient has a legally authorized representative (LAR) who may give written consent to participate in the study Exclusion Criteria: * Current diagnosis of venous thrombosis within the venous tract of the proposed catheter * Diagnosis of peripheral or central vein stenosis (on proposed insertion side) * History or diagnosis of veno-occlusive disease * Diagnosis of superior vena cava syndrome * Known, pre-existing diagnosis of hypercoagulation disorder unrelated to underlying disease * Previous enrollment in this study * Currently pregnant or breast feeding * Skin condition at or within 15 cm of the proposed catheter insertion site, including signs and symptoms of inflammation, rash, crusts, wounds with drainage, sites of intravenous infusion infiltration or extravasation, hematoma, phlebitis and or thrombophlebitis * Medical, social, and/or psychological problems precluding subject from study participation * Known allergy or sensitivity to chlorhexidine