Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.
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hippocampal volume
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
restricted fraction
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Whole brain cerebral blood flow
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Declarative Memory
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Processing speed
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Executive Function
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart