Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.
Age range
12 Years – 17 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
hippocampal volume
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
restricted fraction
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Whole brain cerebral blood flow
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Declarative Memory
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Processing speed
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart
Executive Function
Timeframe: 21 months - Visit 1 and Visit 2 are 21 months apart