The primary outcome of this study is to evaluate the effect of radiofrequency turbinate reduction as an initial treatment on clinical improvement (using visual analogue scale based on total nasal symptoms score, peak nasal inspiratory flow, and turbinate size using ImageJ), inflammatory mediators (ELISA from nasal secretions was performed to measure ECP, IL-5, and HSP-70), and remodeling markers (through nasal biopsy followed by immunohistochemistry examination to evaluate MMP-9, TIMP-1, and PAI-1). In this randomized, controlled trial, 32 patients with moderate-severe persistent AR were randomly divided into 2 groups. Intervention group received radiofrequency turbinate reduction followed by intranasal steroid and antihistamine H-1(AH-1), control group received intranasal steroid and AH-1. Both groups were evaluated for clinical improvement in week 4 and 8 after treatment, inflammatory mediators and remodeling markers in week 4 after treatment.
Age range
18 Years – 70 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
VAS score based on TNSS at baseline
Timeframe: Evaluation is done at baseline
VAS score based on TNSS at week 4
Timeframe: Evaluation is done at week 4
VAS score based on TNSS at week 8
Timeframe: Evaluation is done at week 8
Size of inferior turbinate at baseline
Timeframe: Evaluation is done at baseline
Size of inferior turbinate at week 4
Timeframe: Evaluation is done at week 4
Size of inferior turbinate at week 8
Timeframe: Evaluation is done at week 8
PNIF value at baseline
Timeframe: Evaluation is done at baseline
PNIF value at week 4
Timeframe: Evaluation is done at week 4
PNIF value at week 8
Timeframe: Evaluation is done at week 8
Inflammatory mediators at baseline
Timeframe: Evaluation is done at baseline
Inflammatory mediators at week 4
Timeframe: Evaluation is done at week 4
Remodeling components at baseline
Timeframe: Evaluation is done at baseline
Remodeling components at week 4
Timeframe: Evaluation is done at week 4