Active — Not RecruitingPhase 4

Predictors of Cognitive Outcomes in Geriatric Depression

United States75 participantsStarted 2021-09-28

Plain-language summary

This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.

Who can participate

Age range65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * major depression, single episode or recurrent; * ability to read and write English; * Mini-Mental State Examination \>25. Exclusion Criteria: * lifetime alcohol/drug dependence * conditions associated with brain abnormalities such hydrocephalus, benign and cancerous brain tumors, epilepsy, Parkinson's disease, Huntington's chorea, dementia, demyelinating diseases, etc. * untreated endocrine disorder other than diabetes mellitus * established clinical diagnosis of dementia * other primary psychiatric disorders, e.g., panic disorder, social phobia, obsessive- compulsive disorder, schizoaffective disorder, schizophrenia, bipolar disorder

What they're measuring

Montgomery-Asberg Depression Rating Scale (MADRAS)

Timeframe: Three years

Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Battery Total Score

Timeframe: Three years

Cognitive clinical diagnosis

Timeframe: three years

Trial details

NCT IDNCT05273996

SponsorDavid Steffens

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

View on ClinicalTrials.gov More Major Depressive Disorder trials