CompletedNot Applicable

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

United States55 participantsStarted 2022-06-07

Plain-language summary

To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will undergo three separate acute exposure-episodes of electronic cigarette +/- nicotine and tobacco-cig. The MRI exams and blood draws will be performed pre- and post-exposure. The results will be compared against baseline values derived from a group of non-smokers/non-vapers, who will also undergo a blood draw and MRI.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion Criteria: * BMI: 18.5 to 30 * Current users of electronic cigarettes or tobacco cigarettes with a use history of six months or greater. Exclusion Criteria: * Cancer * HIV * Mental illness in which the participant is not of proper cognizance * Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks) * Serious arrhythmias * Bronchospastic disease * Upper respiratory tract infection within the past six weeks * Medication affecting vascular function * Antibiotics * Magnetic resonance imaging contraindications (metallic implants/intraocular foreign bodies, claustrophobia, cardiac/cochlear implantable electronic devices, etc.)

What they're measuring

Changes in magnetic resonance imaging (MRI) biomarkers of endothelial dysfunction: aortic arch

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Changes in magnetic resonance imaging (MRI) biomarkers of endothelial dysfunction: cerebral vascular reactivity

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Changes in magnetic resonance imaging (MRI) biomarkers of endothelial dysfunction: femoral artery flow-mediated dilation

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Changes in magnetic resonance imaging (MRI) biomarkers of endothelial dysfunction: venous oxygen saturation

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Changes in magnetic resonance imaging (MRI) biomarkers of endothelial dysfunction: blood flow velocity

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Changes in blood inflammatory biomarkers

Timeframe: Pre-Inhalation (baseline) to post-inhalation (60 minutes)

Trial details

NCT IDNCT05271578

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-06

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