Ketamine and Kidney Injury in Cardiac Surgery (NCT05268562) | Clinical Trial Compass
Active — Not RecruitingPhase 4
Ketamine and Kidney Injury in Cardiac Surgery
United States200 participantsStarted 2022-03-02
Plain-language summary
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
Who can participate
Age range
70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
* Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).
Exclusion Criteria:
* Left or right ventricular assist device implantation or explantation.
* Procedures not requiring cardiopulmonary bypass.
* Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded).
* Severe hepatic disease resulting in ascites.
* Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis.
* Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months).
* Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at whether ketamine can reduce acute kidney injury after cardiac surgery — is protecting my kidneys a concern for my specific surgery, and could this be relevant to my situation?
2Since this is a Phase 4 trial, ketamine is already an approved drug, but what do we know so far about how safe and effective it is specifically for preventing kidney injury in cardiac surgery patients like me?
3The trial is active but no longer enrolling new patients — does that mean I've missed the chance to participate, and are there any similar studies currently open that I could consider instead?
4Acute kidney injury is the main thing being measured here — how likely am I personally to develop kidney problems after cardiac surgery based on my health history, and how does that risk factor into my treatment plan?
5If ketamine isn't available to me through this trial, is there anything in my standard care plan that already addresses the risk of kidney injury during or after my heart surgery?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Acute Kidney Injury
Timeframe: Immediately postop up to 10 days postoperatively